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We know they are expensive, but isn’t the cost recouped by the healthcare savings? Dr F. Perry Wilson explains. https://www.medscape.com/viewarticle/glp-1s-are-crazy-effective-just-not-cost-effective-2025a10006es?src=soc_yt --TRANSCRIPT-- Welcome to Impact Factor, your weekly dose of commentary on a new medical study. I’m Dr F. Perry Wilson from the Yale School of Medicine. Much of my time in these videos is spent talking about whether a drug or supplement or diet or intervention works or not. That’s the central focus of medical science: Can we do something for a patient and make a difference in their health? But there’s a related question that we rarely discuss that is almost equally as important: Is this drug or supplement or diet or intervention worth it? And I don’t mean “worth it” in some meta-physical sense. I mean "worth it" in terms of dollars and cents. Is the cost we pay for something worth the benefit we derive from it? I’ll make the argument that the most effective drugs in the past decade are the GLP-1 receptor agonists, drugs like semaglutide and tirzepatide. At least in terms of weight loss, they are truly unparalleled. They are clearly effective. But are they worth it? Are they cost-effective? That is a much harder question, and, as you’ll see in a minute, despite their amazing effects, the answer — for now, at least — is no. How do we decide if a drug is cost-effective? What does that even mean? I’ll give you some extreme examples to illustrate the point a bit. First, for it even to be possible that a drug is cost-effective, it must be effective. It must improve health in some clear, measurable way. Pink jelly beans, while quite inexpensive, do not improve health at all and are therefore not cost-effective. Policymakers should not advocate that insurers cover pink jelly beans. On the flip side are drugs and interventions that actually make money for the system — things that are so good for you, they save money in the long term. The childhood vaccination program is probably the best example of this. The CDC estimates that for every $1 spent on the program, the payer saves about $3 in future costs and society saves about $10 in future costs. This is why insurers have no problem covering childhood vaccines; they would literally be leaving money on the table if they didn’t. So those are the extremes. Don’t pay for pink jelly beans, do pay for vaccines. But we don’t think it is appropriate to cover only stuff that saves money. We are willing to trade money for longer life or quality of life. And this is where the rubber meets the road when it comes to cost-effectiveness analysis: How much is your life worth? To an economist, the answer is basically $100,000 per year of perfect health. The ways they arrive at this number are pretty fascinating, but a lot of it is done by looking at what we as a society are willing to pay for. A cost of $100,000 per “quality-adjusted life year” (QALY) is our standard candle here. More than that is not particularly cost-effective. Less than that is. The “quality” in the QALY is important too. Economists know that a year of perfect health is worth more, in dollar terms, than a year of moderate or poor health. So, if we take an intervention and do some clever modeling based on the price of the intervention and its effectiveness at improving health, we can tell you how much it costs per QALY. Here are a few examples. We have an intervention to pay people to quit smoking. This costs about $2500 per QALY. Seems pretty good. Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/glp-1s-are-crazy-effective-just-not-cost-effective-2025a10006es?src=soc_yt

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Are you looking for a tasty and convenient way to support your keto lifestyle? Look no further than GoKeto Gummies, now available on Amazon. These delicious gummies are packed with all the essential nutrients you need to maintain ketosis and reach your health goals. In this user’s guide, we will explore everything you need to know about GoKeto Gummies, from how to use them to their benefits and potential side effects.

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GoKeto Gummies are a simple and delicious way to supplement your ketogenic diet. Each gummy is packed with essential vitamins and minerals to support your body during ketosis. To use GoKeto Gummies, simply take the recommended dosage each day as part of your regular routine. It’s that easy!

These gummies can be taken with or without food, making them a convenient option for busy lifestyles. It’s important to note that these gummies are not meant to replace a balanced diet but rather to complement it. Be sure to continue eating a variety of healthy foods while using GoKeto Gummies to ensure you are getting all the nutrients your body needs.

For best results, be consistent with your GoKeto Gummies routine. Make it a habit to take them at the same time each day to maximize their benefits. Remember, consistency is key when it comes to seeing results with any supplement.

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There are numerous benefits to using GoKeto Gummies as part of your ketogenic lifestyle. These gummies are specially formulated to support your body during ketosis, making it easier to stay on track with your health goals. Some of the key benefits of GoKeto Gummies include:

1. Increased Energy: The vitamins and minerals in GoKeto Gummies can help boost your energy levels, making it easier to power through your day without feeling sluggish.

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2. Improved Focus: Many users report improved focus and mental clarity when using GoKeto Gummies regularly. This can be especially helpful if you’re following a strict ketogenic diet and need to stay sharp throughout the day.

3. Enhanced Weight Loss: By supporting your body with essential nutrients, GoKeto Gummies can help promote weight loss and fat burning while following a ketogenic diet. Combined with healthy eating and regular exercise, these gummies can be a valuable tool in reaching your weight loss goals.

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