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In this episode of the Pharm So Hard Podcast, the hosts discuss GLP-1 receptor agonists, a class of medications used to manage blood sugar levels in patients with type 2 diabetes and to treat obesity. They provide an overview of the history and development of GLP-1 receptor agonists, highlighting their clinical superiority and various benefits. The hosts also explain the role of GLP-1s in the body, including their glucose-dependent insulin secretion and effects on gastric emptying. They discuss the impact of GLP-1s on hunger and mental health, emphasizing the reduction of food noise and improvement in satiety levels. Additionally, they differentiate GLP-1 receptor agonists for diabetes and weight loss and explore their indications and guideline positioning. Takeaways • GLP-1 receptor agonists are a class of medications used to manage blood sugar levels in patients with type 2 diabetes and to treat obesity. • GLP-1 receptor agonists have shown clinical superiority to other anti-hyperglycemic drugs, improving glycemic control, reducing weight loss and blood pressure, and providing cardio-protective benefits. • GLP-1s increase glucose-dependent insulin secretion, block glucagon secretion, and slow gastric emptying, leading to improved blood sugar control and increased satiety. • GLP-1 receptor agonists have a positive impact on mental health, reducing food noise and helping individuals make healthier food choices. • Different GLP-1 receptor agonists have specific indications for diabetes and weight loss, and their use is guided by clinical guidelines. • GLP-1 receptor agonists are FDA-approved for improving glycemic control in patients with type 2 diabetes and for the treatment of obesity. • The choice of GLP-1 receptor agonist depends on factors such as comorbidities, weight loss goals, and patient preferences. • GLP-1 receptor agonists have different dosing regimens, and the specific dose may vary based on the indication and the product. • Common side effects of GLP-1 receptor agonists include nausea, vomiting, and diarrhea, but these side effects often improve with continued use and proper management. GLP-1 agonists can cause loss of appetite as a side effect. • GLP-1s are being used off-label for conditions such as NAFLD and depression. • GLP-1s may have positive effects on bone health and blood pressure. • The high cost of GLP-1s poses challenges for patient access. Chapters 00:00 Introduction to GLP-1 Receptor Agonists 01:12 History and Development of GLP-1 Receptor Agonists 06:14 The Role of GLP-1s in the Body 09:38 Effects of GLP-1s on Hunger and Mental Health 11:17 Differentiation of GLP-1 Receptor Agonists for Diabetes and Weight Loss 11:44 Indications and Guideline Positioning of GLP-1 Receptor Agonists

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