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(https://isappscience.org/wp-content/uploads/2025/07/Greiner-cover.png) This episode features Dr. Thomas Greiner PhD from the University of Gothenburg (Sweden), speaking about the various functions of GLP-1 in the gut, and the role of gut microbes in GLP-1 production, with ultimate effects on host health. He noted that GLP-1 is produced by enteroendocrine cells called L-cells, both in the small intestine and the colon. These cells respond to nutrients and microbially-produced short-chain fatty acids, but responses differ between the small intestine and colon, leading Dr. Greiner to investigate the different functions of GLP-1 at these two sites. Using germ-free mice and other models, Dr. Greiner has developed a hypothesis that the function of GLP-1 in the small intestine is to improve insulin secretion postprandially, whereas the functions of GLP-1 in the colon are to allow for increased energy intake (in a situation of energy deficiency), dampen inflammation, and protect local tissues. He and his colleagues are taking two different approaches in aiming to improve metabolic health in humans: finding inhibitors of bacterial enzymes to decrease production of a harmful molecule produced by bacteria; and a probiotic approach of administering butyrate-producing bacteria. With the latter approach, the sensitivity of the bacteria to oxygen is a problem to overcome, but their group has evolved a bacterial strain to tolerate some oxygen, with the idea of testing it as a probiotic. Episode abbreviations and links: • Paper exploring the role of the gut microbiota in GLP-1 signaling: GLP-1R signaling modulates colonic energy metabolism, goblet cell number and survival in the absence of gut microbiota (https://www.sciencedirect.com/science/article/pii/S2212877824000553?via%3Dihub) • Study on the functions of GLP-1 in the colon: Microbial Modulation of Energy Availability in the Colon Regulates Intestinal Transit (https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(13)00365-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS193131281300365X%3Fshowall%3Dtrue) • Bäckhed Lab Instagram account: @backhed_lab (https://www.instagram.com/backhed_lab?igsh=MWdpdmlndDAxOWFjag==) About Dr. Thomas Greiner PhD: Thomas Greiner is a medical scientist at the Wallenberg Laboratory, University of Gothenburg, with over 15 years of experience in functional genetics and metabolic research. His work focuses on the intricate interplay between gut microbiota, intestinal hormones such as GLP-1, and host metabolism. He has explored how microbial and hormonal signals influence energy balance, intestinal function, and the development of metabolic diseases. His research primarily uses molecular approaches in mouse models to investigate the role of microbial signals in metabolic disease and to uncover new functions of gut hormones in regulating intestinal physiology. Sign up (https://isappscience.org/for-scientists/news/isapp-newsletters/) for our monthly newsletter Follow us (https://isappscience.org/contact/) on LinkedIn, Bluesky, X, Facebook, Instagram, Threads The post Unraveling the functions of GLP-1 in the gut, with Dr. Thomas Greiner PhD (https://isappscience.org/episode-65-unraveling-the-functions-of-glp-1-in-the-gut/) appeared first on International Scientific Association for Probiotics and Prebiotics (ISAPP) (https://isappscience.org) .

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Are you struggling to shed those extra pounds and looking for a solution to help you reach your weight loss goals? Diet pills can be a great option for those looking to accelerate their weight loss journey and see results faster. With so many options on the market, it can be overwhelming to choose the best diet pill for weight loss. In this article, we will explore some of the top formulas for 2023 to help you make an informed decision and kickstart your weight loss journey.

PhenQ: A Comprehensive Weight Loss Solution

PhenQ is a powerful weight loss formula that combines multiple benefits to help you achieve your weight loss goals. This all-in-one solution helps boost your metabolism, suppress your appetite, and increase your energy levels, making it easier for you to stick to your diet and exercise routine. PhenQ also contains ingredients that can block fat production in the body, making it easier to prevent weight gain. With regular use, PhenQ can help you achieve long-lasting results and maintain a healthier weight.

One of the key ingredients in PhenQ is α-Lacys Reset®, a scientifically proven formula that accelerates your body’s metabolism and helps burn calories faster. This unique blend of ingredients sets PhenQ apart from other weight loss supplements on the market, making it a top choice for individuals looking to lose weight effectively. Additionally, PhenQ is manufactured in FDA-approved facilities, ensuring high quality and safety standards.

For optimal results, it is recommended to take PhenQ twice a day with a glass of water, preferably before breakfast and lunch. Combined with a healthy diet and regular exercise, PhenQ can help you achieve your weight loss goals and improve your overall well-being. Say goodbye to stubborn fat and hello to a healthier, happier you with PhenQ.

Leanbean: The Ultimate Fat Burner for Women

Leanbean is a specially formulated weight loss supplement designed specifically for women. This powerful fat burner is made with natural ingredients that target stubborn fat areas, such as the hips, thighs, and belly. Leanbean helps suppress your appetite, boost your metabolism, and increase your energy levels, making it easier for you to stick to your weight loss goals.

One of the key ingredients in Leanbean is konjac fiber, a natural appetite suppressant that helps you feel full and satisfied for longer periods. This can help reduce your calorie intake and prevent overeating, making it easier to stick to a healthy diet. Leanbean also contains green tea extract, which boosts your metabolism and helps burn fat more efficiently.

With regular use, Leanbean can help you achieve a leaner, more toned physique and improve your overall health and well-being. This natural formula is free from harmful chemicals and additives, making it a safe and effective option for women looking to lose weight. Say goodbye to cravings and hello to a healthier, more confident you with Leanbean.

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Instant Knockout: The Ultimate Fat Burner for Men

Instant Knockout is a powerful weight loss supplement designed specifically for men looking to shed excess body fat and achieve a more defined physique. This cutting-edge formula helps boost your metabolism, increase your energy levels, and enhance your workout performance, making it easier to burn fat and build lean muscle mass.

One of the key ingredients in Instant Knockout is cayenne pepper extract, a natural metabolism booster that helps your body burn calories more efficiently. This ingredient also helps suppress your appetite and reduce cravings, making it easier to stick to your weight loss goals. Instant Knockout also contains green tea extract, which helps increase your energy levels and improve fat oxidation.

For best results, it is recommended to take Instant Knockout four times a day with a meal or snack. Combined with a healthy diet and regular exercise routine, Instant Knockout can help you achieve a shredded physique and boost your confidence and self-esteem. Say goodbye to stubborn belly fat and hello to a more confident, healthier you with Instant Knockout.

Trimtone: The Natural Fat Burner for Busy Women

Trimtone is a natural fat burner designed specifically for women with busy lifestyles. This powerful formula helps boost your metabolism, suppress your appetite, and increase your energy levels, making it easier for you to stay on track with your weight loss goals. Trimtone contains natural ingredients that target stubborn fat areas, such as the thighs, hips, and belly.

One of the key ingredients in Trimtone is green coffee bean extract, a natural metabolism booster that helps your body burn fat more efficiently. This ingredient also helps regulate blood sugar levels and reduce cravings, making it easier to adhere to a healthy diet. Trimtone also contains caffeine, which boosts your energy levels and enhances your focus and alertness.

For optimal results, it is recommended to take Trimtone once a day with a glass of water before breakfast. Combined with a healthy diet and regular exercise routine, Trimtone can help you achieve a slimmer, more toned physique and improve your overall health and well-being. Say goodbye to fatigue and hello to a healthier, more energetic you with Trimtone.

FAQs

Q: Are diet pills safe for weight loss?

A: When used as directed and in conjunction with a healthy diet and exercise routine, diet pills can be a safe and effective way to accelerate weight loss. It is important to choose a reputable brand and follow the recommended dosage instructions to minimize any potential side effects.

Q: How quickly can I expect to see results with diet pills?

A: Results may vary depending on the individual, but most people start to see noticeable results within a few weeks of taking diet pills. Consistent use, combined with a healthy lifestyle, can help you achieve your weight loss goals faster and maintain long-term results.

Q: Can I take multiple diet pills at the same time?

A: It is not recommended to take multiple diet pills at the same time, as this can increase the risk of side effects and interactions between ingredients. It is best to choose one reputable brand and follow the recommended dosage instructions for optimal results.

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A singer should avoid foods that produce phlegm or cause regurgitation in the esophagus, such as dairy, wheat and hot, spicy foods. Pay attention to your body as a singer, particularly the throat and chest area, with advice from a nutritional consultant in this free video on diets. Expert: Charlotte Skiles Contact: www.charlotteskiles.com Bio: Charlotte Skiles is the founder of Eat in Peace Wellness Consulting, in Austin, Texas. Filmmaker: Todd Green

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