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Presentación académica sobre Orforglipron (LY3502970), el primer agonista oral no peptídico del receptor GLP-1 con eficacia clínicamente comprobada en el tratamiento de la obesidad y la diabetes mellitus tipo 2 (DM2). Este video revisa su historia, estructura química, mecanismo de acción, eficacia en ensayos clínicos fase 1, 2 y 3, así como sus perspectivas regulatorias globales. ▪ Autor: Dr. Héctor Iván Saldívar Cerón ▪ Facultad de Estudios Superiores Iztacala, UNAM ▪ Proyecto vinculado: PAPIME 203825 · PAPIIT IA201725 · FICDTEM-2023-131 Referencias: 1. Rosenstock J et al. Lancet, 2023. 2. Wharton S et al. NEJM, 2023. 3. Pratt E et al. Diabetes Obes Metab, 2023. 4. Lilly Press Release, 2025.

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