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Recently David Sinclair was interviewed by Sam Bakhtiar, Sam is a doctor, an author and a was world-class bodybuilder.
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Discovered by David Sinclair PhD, NMN or Nicotinamide Mononucleotide is the pre-cursor to NAD+ (Nicotinamide Adenine Dinucleotide), NAD is found in nearly all our living cells. NAD is essential for sustaining life. Dr. David Sinclair (a professor at Harvard Medical School) once said if we suddenly didn’t have NAD we would be dead within eight seconds.’ Unfortunately, as we age our NAD levels drastically decline, clinical studies have shown that by age of 50 a typical person could have half the NAD+ they did in their youth and by the age of 80 our NAD+ (Nicotinamide Adenine Dinucleotide) levels drop to around 1% to 10% of those enjoyed in our youth. NAD is biologically unstable, which makes it unsuitable for oral supplementation. Fortunately, it is easy to restore our cellular NAD levels using NMN (Nicotinamide Mononucleotide) or NR (Nicotinamide Riboside), which convert to NAD when it is in the cell. These NAD boosting supplements can be purchased from reputable companies such as Do Not Age, Alive by Science and Pro-health Longevity, however there are many unscrupulous companies selling fake NMN, so buyer beware. Dr. David Sinclair confirms that a fascinating aspect of NAD+ is its dual role in protecting against factors that age us. This includes mitigating chemical stress, inflammation, DNA damage and failing mitochondria; all conditions associated with aging. In other words, while a decline in NAD+ levels may negatively influence lifespan and Healthspan (health-span), so restoring NAD+ is increasingly being viewed as a scientific way to promote longevity and a way to combat the diseases of aging too. A rigorous scientific review of NAD+ reveals that its longevity benefits arise from eight different, but interrelated, functions. In 2013 a scientific study; 2-year old mice were tested for muscle wastage, insulin resistance and inflammation, all are, on humans used as indicators of the aging process, they were then given NMN (Nicotinamide Mononucleotide) for 1 week. In all cases, after only 1 week the 2-year old mice were reflecting the expected findings of 6-month old mice in the areas of muscle wastage, insulin resistance and inflammation. In human terms that would be comparable to a 75-year old having the results you would expect from a 25-year old. In a later methodical study, in 2018, again on mice, Dr. David Sinclair’s team at the Harvard Medical School found that the aging of blood vessels had been reversed.
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Berberine for PCOS. Can Berberine Really Help With PCOS. Berberine Dosage. How to Take Berberine. Berberine for Women. Does Berberine Mess With Hormones. 📌 Get 10% off Thorne Berberine 👉 https://s.thorne.com/nV15a 📌 Get 10% of all Thorne Supplements ⬇️ 👉 https://www.thorne.com/u/DrArsalanAspires Watch Berberine Weight: ➡️ https://youtu.be/2ywYB_dJDf0 Watch How to Take Berberine: ➡️ https://youtu.be/4vdOs8CkFmg Timeline | Chapters 00:00 - PCOS 1:07 - What Causes PCOS 1:52 - The Hidden Cause of PCOS 2:10 - How Does Berberine Help PCOS 4:20 - What is The Best Berberine? 5:30 - Add This to Berberine What Is PCOS and How Does Berberine Help? Polycystic ovary syndrome (PCOS) is a hormonal imbalance that affects millions of women globally. Its core symptoms include: Irregular or absent menstrual cycles, Elevated androgens (male hormones like testosterone), Ovarian dysfunction, Skin concerns, such as acne or excess facial hair, and Insulin resistance, which disrupts hormone regulation and ovarian function. Insulin resistance is considered a central feature of PCOS. When the body becomes less responsive to insulin, the pancreas produces more of it, which can overstimulate the ovaries and lead to increased production of androgens. This hormonal imbalance results in irregular cycles, excess hair growth (hirsutism), and ovulatory dysfunction. How Berberine Works for PCOS Improves Insulin Sensitivity The most well-documented benefit of berberine for PCOS is its ability to enhance insulin sensitivity. It activates an enzyme called AMP-activated protein kinase (AMPK), which plays a central role in regulating how the body uses energy. Activating AMPK helps: Improve cellular glucose uptake, Lower fasting insulin levels, Reduce the liver’s production of glucose, Stabilize post-meal blood sugar levels. In studies, berberine has performed as well as metformin, a prescription medication commonly used for insulin resistance in PCOS. Unlike metformin, berberine tends to cause fewer digestive side effects for many women. Reduces Androgen Levels PCOS is often characterized by elevated levels of testosterone and other androgens, which contribute to symptoms like acne, oily skin, and hirsutism (unwanted facial or body hair). Clinical studies have shown that berberine can help lower total testosterone and DHEA-S levels, which contributes to a more balanced hormonal environment. By lowering excess androgens, berberine may help: Clear acne-prone skin, Reduce unwanted hair growth, and Normalize ovulatory function. #berberine
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