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Daily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity NEJM : DOI: 10.1056/NEJMoa2302392 Orforglipron es un agonista oral no peptídico del receptor GLP-1 que se está desarrollando para el control del peso y el tratamiento de la diabetes tipo 2. Orforglipron actúa como un potente agonista parcial del receptor GLP-1. GLP-1 (Péptido similar al glucagón-1) es una hormona que juega un papel en la regulación de la glucosa y el control del apetito. Orforglipron tiene un mecanismo único de activación del receptor GLP-1. Produce señalización cAMP similar a la producida por el GLP-1 nativo. Sin embargo, conduce a una baja activación de la vía β-arrestina, que regula la internalización del receptor. Este efecto de señalización sesgada puede contribuir a su eficacia. 272 participantes fueron asignados aleatoriamente para recibir diferentes dosis de orforglipron: 12 mg, 24 mg, 36 mg, etc. Participantes del Estudio: El estudio se centró en participantes que tenían obesidad (índice de masa corporal IMC 30) o estaban con sobrepeso (IMC entre 27 a 30) con al menos una condición relacionada con el peso, como hipertensión, dislipidemia, enfermedad cardiovascular o apnea obstructiva del sueño. Se requería que los participantes tuvieran un peso corporal estable (5% de ganancia o pérdida) durante los 3 meses anteriores a la aleatorización. Semana 26: Orforglipron 12 mg: -9.0 kg Orforglipron 24 mg: -12.3 kg Orforglipron 36 mg: -12.9 kg Orforglipron 45 mg: -13.3 kg Placebo: -2.1 kg Semana 36: Orforglipron 12 mg: -9.8 kg Orforglipron 24 mg: -13.6 kg Orforglipron 36 mg: -14.2 kg Orforglipron 45 mg: -15.4 kg Placebo: -2.4 kg Estos valores representan el cambio medio estimado en el peso corporal desde el inicio para cada grupo. Se observó que la reducción de peso dependía de la dosis, con dosis más altas de Orforglipron resultando en una mayor pérdida de peso en comparación con el grupo placebo.
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Shed belly fat and tone your core with this quick and effective 5-minute standing workout. This routine is designed to engage your abs, obliques, and lower body while keeping you on your feet—no floor exercises needed! Perfect for busy days, this workout will help you burn calories and tighten your midsection. Start with Side Bends (L) and (R) to warm up your obliques and stretch your sides. Transition into Single Air Bike (L) and (R) to activate your lower abs and improve balance. Next, engage your entire core with Standing Ankle Taps, a dynamic movement that strengthens your abs while keeping your heart rate up. This routine ensures you’re targeting your belly fat while building a stronger, more defined core. Commit to these moves daily, and you’ll notice a leaner, more toned midsection in no time—all without ever needing to get on the floor! 📝 EXERCISE LIST 📝 0:20 Side Bends (L) 1:09 Side Bends (R) 2:15 Single Air Bike (L) 3:05 Single Air Bike (R) 4:10 Standing Ankle Taps
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Emily Field, Barclays head of European pharmaceutical research, joins 'Squawk Box' to discuss the state of the weight loss drug market, disappointing trial results of Novo Nordisk's experimental CagriSema weight loss drug, and more.
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