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🚀 Stay ahead in combination products, pharma, and medical devices 👉 https://www.letscombinate.com 🎙️ Listen to more expert discussions on regulations, drug delivery, and quality 👉 https://www.letscombinate.com/ Get expert insights on FDA regulations, risk management, quality systems, and the latest trends in drug-device combination products. Ben Locwin discusses the science, quality, and future of GLP-1 receptor agonists, revolutionary drugs used in diabetes and obesity treatment. The episode explores the history and development of GLP-1s, their commercial viability, manufacturing challenges, and regulatory landscapes. Ben dives into the mechanisms of GLP-1s, including their influence on appetite, blood sugar, and gastrointestinal effects. They also touch on the capacity issues in production, the impact of compounding, and the sustainability concerns associated with injector pens. The conversation provides an in-depth look at the pharmaceutical industry’s response to the surge in GLP-1 demand, highlighting the broader implications for patient care and market trends. 00:00 Introduction to GLP Receptor Agonists 00:46 Guest Introduction: Ben Locwin 01:48 Historical Context of GLP-1 Development 05:54 Mechanisms and Effects of GLP-1 09:51 Market Impact and Manufacturing Challenges 11:16 Regulatory and Advertising Considerations 17:44 Sustainability and Injector Pen Issues 19:40 Risk Management and Future Directions 23:31 Conclusion Ben Locwin is a Healthcare Executive, MMA fighter, Jiu Jtisu pro and Quality and Regulatory SME working in medical devices, pharma and other regulated industries. Subhi Saadeh is a Quality Professional and host of Let's Combinate. With a background in Quality, Manufacturing Operations and R&D he's worked in Large Medical Device/Pharma organizations to support the development and launch of Hardware Devices, Disposable Devices, and Combination Products for Vaccines, Generics, and Biologics. Subhi serves currently as the International Committee Chair for the Combination Products Coalition(CPC) and as a member of ASTM Committee E55 and also served as a committee member on AAMI's Combination Products Committee. For questions, inquiries or suggestions please reach out at letscombinate.com or on the show's LinkedIn Page.
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Fiber And The Keto Diet? In this informative video, we’ll discuss the role of fiber in the ketogenic diet and its importance for overall health. Fiber is a key component of our diet, contributing to digestive health, regulating blood sugar levels, and supporting heart health. However, with the restrictions on carbohydrate intake in the keto diet, many individuals may find it challenging to meet their fiber needs. We’ll explore how this can lead to digestive issues, including constipation, and how a lack of fiber can affect gut health and disease prevention.
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Understanding the balance between the benefits of the ketogenic diet and the necessity of fiber can help you achieve your health goals while minimizing risks associated with low fiber intake. Join us for this essential discussion, and subscribe to our channel for more helpful information on diet, nutrition, and health management.
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Researchers found a new molecule in the blood that is produced during intense exercise and reduces food intake and promotes weight loss in mice. Then they connected this "anti-hunger" molecule to the moderate weight loss that happens when people take metformin for diabetes. The molecule is name lac-phe since its produce from lactate, which can come from exercising muscles ,and the amino acid phenylalanine inside intestinal cells. Once released it’s thought that lac-phe influence hunger centers in the brain to reduce appetite.
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