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Book a FREE 15-minute Rapid Nutrition Assessment, designed to fine-tune your strategy, identify your #1 roadblock, and give you a personalized 3-step action plan in a fast-paced 15 minutes: https://witsandweights.com/free-call — Are your long runs and cardio sessions actually making fat loss harder? Could walking be more effective for your physique and longevity? I bring on former pro triathlete and Olympic coach Brad Kearns @brad.kearns to challenge the conventional wisdom around running and fat loss. Brad explains why chronic cardio may sabotage your metabolism, increase your appetite, and even make you lazier. Brad Kearns is a two-time US national champion and a former #3 world-ranked professional triathlete. He is the co-author of Born to Walk with Mark Sisson. Brad is a coach, researcher, and speaker focused on longevity, fat loss, and performance. *Today, you’ll learn all about:* 0:00 – Intro 02:02 – Why running is the second most dangerous sport after football 06:09 – The genetic flaw in the argument that humans are "Born to Run" 09:24 – How chronic cardio affects metabolism and fat loss 14:07 – Why most calorie burn calculations are totally inaccurate 20:26 – Walking is anabolic, running is catabolic—here’s why 29:02 – The best way to sprint for fat loss (without burnout) 38:09 – Why endurance runners tend to be lazier throughout the day 44:46 – The fat max heart rate and why most people run too fast 54:36 – How to run without destroying your metabolism or joints 1:03:13 – Outro *Episode resources:* Free bonuses when you buy the book: https://borntowalkbook.com The B.rad Podcast: https://podcasts.apple.com/us/podcast/the-b-rad-podcast/id1430171257 Website: https://bradkearns.com 👩‍💻 Book a FREE 15-Minute Rapid Nutrition Assessment: https://witsandweights.com/free-call 👥 Join our Facebook community for live Q&As & support: https://bit.ly/3vyLDqO 👋 Let's connect! Ask a question (https://www.witsandweights.com/question), get my FREE newsletter (https://witsandweights.com/email), or find me on Instagram (https://www.instagram.com/witsandweights/) 📱 Try MacroFactor for free with code WITSANDWEIGHTS: https://www.witsandweights.com/blog/macrofactor 🏋️‍♀️ Download Boostcamp for free for evidence-based workout programs: https://boostcamp.app/#witsandweights 🫙 Get 20% off Legion supplements with code WITSpod https://legionathletics.rfrl.co/nj885 🩷 Leave a 5-star review if you love the podcast! https://podcasts.apple.com/us/podcast/wits-weights-nutrition-lifting-muscle-metabolism-fat-loss/id1591502355

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00:00 - Novo Nordisk vs. Compounding Pharmacies: Ozempic & Wegovy Under Pressure | Market Talk 2025 01:37 - Novo Nordisk Cuts Wegovy Sales Forecast: What You Need to Know 1. Novo Nordisk vs. Compounding Pharmacies: Ozempic & Wegovy Under Pressure | Market Talk 2025 Novo Nordisk • Ozempic • Wegovy • Obesity drug market In this Market Talk roundup, we break down Barclays' latest analysis on Novo Nordisk after the firm trimmed guidance amid rising competition from compounding pharmacies. Discover: • Why Ozempic & Wegovy are still on track to shape the biggest therapeutic market ever • How knock-off weight-loss injections from compounding pharmacies are denting near-term sales • What Novo Nordisk’s lawsuits could mean for future revenue • Investor reaction: NVO shares slip 2.9% on the news Tune in for concise stock insights, healthcare sector trends, and what to watch next in the booming obesity-treatment space. Key takeaways for traders, healthcare professionals, and anyone tracking the weight-loss drug race! 2. Novo Nordisk Cuts Wegovy Sales Forecast: What You Need to Know In this video, we discuss Novo Nordisk's recent decision to lower its sales forecast for the obesity drug Wegovy, attributing the change to competition from compounded versions. We explore the implications of this decision, the role of compounding pharmacies, and what it means for patients and the market. Learn about the new CEO of Novo Nordisk, Maziar Mike Doustdar, and how the company plans to tackle the challenges ahead. Stay informed about the latest developments in the pharmaceutical industry and the ongoing debate around compounded medications. - Novo Nordisk's sales forecast cut explained - The impact of compounded drugs on the market - Insights from health economists and industry experts - The future of Wegovy and obesity treatments Don't forget to like, share, and subscribe for more updates!

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Weight loss is a journey that many people embark on for various reasons, whether it’s to improve their health, feel more confident, or simply to fit into their favorite pair of jeans. Over the years, numerous weight loss medications have been introduced to help individuals achieve their goals. One such medication that has gained popularity recently is Semaglutide. This drug, originally developed to treat type 2 diabetes, has been shown to have significant weight loss benefits. But how long does it take for Semaglutide to show results?

The Mechanism of Semaglutide for Weight Loss

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, which means that it mimics the action of a hormone called GLP-1 in the body. GLP-1 is naturally produced in the gut and plays a crucial role in regulating blood sugar levels and appetite. When Semaglutide is injected, it binds to GLP-1 receptors in the brain, signaling feelings of fullness and reducing food intake. This leads to a decrease in calorie consumption and ultimately, weight loss.

Short-Term Effects of Semaglutide

Studies have shown that Semaglutide can lead to significant weight loss in the short term. In a 68-week clinical trial, patients who received a 2.4 mg dose of Semaglutide lost an average of 14.9% of their body weight, compared to 2.4% in the placebo group. These results were observed after just 16 weeks of treatment, indicating that Semaglutide can produce rapid weight loss effects.

Long-Term Effects of Semaglutide

While Semaglutide has shown impressive short-term weight loss results, the effects over the long term are even more promising. In another study that followed patients for 68 weeks, those who continued treatment with Semaglutide maintained their weight loss and even continued to lose more weight over time. This suggests that Semaglutide not only helps individuals shed pounds quickly but also supports sustained weight loss in the long run.

Factors Affecting Response to Semaglutide

It’s important to note that individual responses to Semaglutide may vary. Factors such as initial body weight, diet, exercise habits, and overall health can impact how quickly someone sees results with this medication. For some individuals, weight loss may be more gradual, while others may experience rapid changes. It’s essential to work closely with a healthcare provider to monitor progress and adjust treatment as needed.

Combining Semaglutide with Lifestyle Changes

While Semaglutide can be an effective tool for weight loss, it works best when combined with healthy lifestyle changes. A balanced diet, regular exercise, and adequate sleep are key components of a successful weight loss journey. By incorporating these habits alongside Semaglutide treatment, individuals can maximize their results and maintain a healthy weight in the long term.

In conclusion, Semaglutide can produce rapid and sustained weight loss effects in individuals struggling to shed excess pounds. While the timeline for seeing results may vary, many patients experience significant changes within a few weeks of starting treatment. By understanding the mechanism of Semaglutide, its short-term and long-term effects, and the importance of lifestyle modifications, individuals can achieve their weight loss goals with this medication.

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