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Inhibitors of dipeptidyl peptidase 4 (DPP-4 inhibitors or gliptins) are a class of oral hypoglycemics that block the enzyme dipeptidyl peptidase-4 (DPP-4). They can be used to treat diabetes mellitus type 2. The first agent of the class – sitagliptin – was approved by the FDA in 2006.[1] Glucagon increases blood glucose levels, and DPP-4 inhibitors reduce glucagon and blood glucose levels. The mechanism of DPP-4 inhibitors is to increase incretin levels (GLP-1 and GIP),[2][3][4] which inhibit glucagon release, which in turn increases insulin secretion, decreases gastric emptying, and decreases blood glucose levels. A 2018 meta-analysis found no favorable effect of DPP-4 inhibitors on all-cause mortality, cardiovascular mortality, myocardial infarction or stroke in patients with type 2 diabetes.[5] ExamplesEdit Drugs belonging to this class are: Sitagliptin[6] (FDA approved 2006, marketed by Merck & Co. as Januvia) Vildagliptin[7] (EU approved 2007, marketed in the EU by Novartis as Galvus) Saxagliptin (FDA approved in 2009, marketed as Onglyza) Linagliptin (FDA approved in 2011, marketed as Tradjenta by Eli Lilly and Company and Boehringer Ingelheim)[8] Gemigliptin (approved in Korea in 2012, marketed by LG Life Sciences)[9] Marketed as Zemiglo Anagliptin (approved in Japan in 2012, marketed by Sanwa Kagaku Kenkyusho Co., Ltd. and Kowa Company, Ltd.)[10] Teneligliptin (approved in Japan in 2012[11]) Alogliptin (FDA approved 2013, marketed by Takeda Pharmaceutical Company) Trelagliptin (approved for use in Japan in 2015) Omarigliptin (MK-3102) (approved in Japan in 2015,[12] developed by Merck & Co.; research showed that omarigliptin can be used as once-weekly treatment and generally well-tolerated throughout the base and extension studies[13]) Evogliptin (approved for use in South Korea[14]) Gosogliptin (approved for use in Russia[15]) Dutogliptin (being developed by Phenomix Corporation), Phase III[16] Other chemicals which may inhibit DPP-4 include: Berberine, an alkaloid found in plants of the genus Berberis, inhibits dipeptidyl peptidase-4 which may at least partly explains its antihyperglycemic activity.[17] Adverse effectsEdit In those taking sulphonylureas, there is an increased risk of low blood sugar.[18] Adverse effects, including nasopharyngitis, headache, nausea, heart failure, hypersensitivity and skin reactions. The U.S. Food and Drug Administration (FDA) is warning that the type 2 diabetes medicines like sitagliptin, saxagliptin, linagliptin, and alogliptin may cause joint pain that can be severe and disabling. FDA has added a new Warning and Precaution about this risk to the labels of all medicines in this drug class, called dipeptidyl peptidase-4 (DPP-4) inhibitors.[19] However, studies assessing risk of rheumatoid arthritis among DPP-4 inhibitor users have been inconclusive.[20] A 2014 review found increased risk of heart failure with saxagliptin and alogliptin, prompting the FDA in 2016 to add warnings to the relevant drug labels.[21] A 2018 meta analysis showed that use of DPP-4 inhibitors was associated with a 58% increased risk of developing acute pancreatitis compared with placebo or no treatment.[22] A 2018 observational study suggested an elevated risk of developing inflammatory bowel disease (specifically, ulcerative colitis), reaching a peak after three to four years of use and decreasing after more than four years of use.[23] CancerEdit In response to a report of precancerous changes in the pancreases of rats and organ donors treated with the DPP-4 inhibitor sitagliptin,[24][25] the United States FDA and the European Medicines Agency each undertook independent reviews of all clinical and preclinical data related to the possible association of DPP-4 inhibitors with pancreatic cancer. In a joint letter to the New England Journal of Medicine, the agencies stated that they had not yet reached a final conclusion regarding a possible causative relationship.[26] A 2014 meta-analysis found no evidence for increased pancreatic cancer risk in people treated with DPP-4 inhibitors, but owing to the modest amount of data available, was not able to completely exclude possible risk.[27] Combination drugsEdit Some of the DPP-4 inhibitor drugs have gotten approval from the FDA to be used with metformin concomitantly with additive effect to increase the level of glucagon-like peptide 1 (GLP-1) which also decreases hepatic glucose production.[28]

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Have you ever wondered how a celebrity transforms their appearance and the reactions that follow? Christina Aguilera's recent journey is a captivating example of this phenomenon. The renowned artist has been turning heads with her impressive 40-pound weight loss, which has sparked curiosity and a swirl of rumors regarding possible methods behind her transformation.

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Hello Everyone, today’s Video is all about Can You Lose Weight & Belly Fat With Walking ? Benefits & Tips for Using Walking for Weight Loss. Walking Is the best form of physical activity that is easy, low risk, convenient, free accessible to most of the people. Walking burns calories, which can help you lose weight and keep it off. Today, I have shared some useful tips on how to get started and how to prepare yourself for walking to lose maximum weight. This video highlights some useful benefits of walking. Also Correct posture, speed you need to get maximum result from walking. Calories you can burn with walking and if you can use weight only with walking. Towards the end I have included some basic tips for beginners, who are taking up walking as their prime physical activity for weight loss. For more videos & updates do Subscribe: https://www.youtube.com/c/FoodFitnessFun Follow us on Instagram: https://www.instagram.com/foodfitnessnfun/ Subscribe to my Recipe channel @FitFood Flavours: https://www.youtube.com/channel/UCGmT2ItseDCcJbJDGIpHp6w Visit Our Website to find Written English version of the videos: https://www.foodfitnessnfun.com/ 👉 Recent videos I have posted on my Channel Bad Winter Food Combinations to Avoid https://youtu.be/SN7jYBGRgR4 Magical winter tea for Weight Loss https://youtu.be/UlJG8pEwJyE Diet plan for women for hormonal balance https://youtu.be/r45ce6dSN_U Indian tips for Intermittent Fasting https://youtu.be/3-iXngH5Qac How to automatically lose weight permanently https://youtu.be/h7_eF-ZZHn0 Best Exercise for PCOS PCOD https://youtu.be/TJkIJJULyv4 Healthy snack Recipes for Weight loss https://youtu.be/rqRPwBr_83A 5 Winter Morning Drink Recipes https://youtu.be/oIv8Dddux5Y Full lower body workout for slim thighs & Hips https://youtu.be/ZY0hX64_uOs #foodfitnessfun #fitfoodflavours *The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. * Keywords & Tags Used Can You Lose Weight with walking Lose Belly Fat With Walking Benefits of walking Walking Tips Walking for Weight Loss How to lose weight with walking How much you should walk Calories burn in walking How much warm in a day Walking to lose belly fat Walking to Lose Weight Walking and weight loss Right technique for walking Correct posture for walking Tips for walking Walking workout Walking tips for beginners How much to walk daily 10000 steps for weight loss Lizzo Shares Insight Into Monthslong Progress Amid Weight Loss Journey E News

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This video describes the procedure of the swallow pill balloon by allurion for weight loss. It is a painless, safe and effective procedure for weight loss which can help in loss of 15-20 kgs within 4-6 months. The balloon is packaged into a small capsule with a fine catheter attached to it. The capsule is swallowed by the patient in the doctor's office with some water and its position in the stomach is confirmed with the help of an X ray. The catheter is then used to instill fluid inside the balloon which then takes the shape of a large ball inside the stomach. The catheter is detached and patient can be sent back home. The balloon occupies a lot of space inside the stomach and reduces hunger and promotes satiety. This leads to a caloric deficit in the body which translates into a gradual weight loss. The weight loss continues till the balloon is inside the stomach. After a period of around 4 months, a timed valve inside the balloon opens and the fluid is expelled. This causes the balloon to be excreted outside the body along with stools. The balloon has shown to reduce upto 15-20% total body weight and should be accompanied with positive lifestyle changes like proper diet and exercise.

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