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Discussion with Dr. Michael Epitropolous and Dr. Steven Balestracci about the side effects of synthetic semaglutide. For more info, please visit https://weightlossthatworks.fit The Surprising Risks of Ozempic and Wegovy In recent years, the prescription GLP-1 agonist medications Ozempic, Wegovy, Maunjaro, and Zepbound have gained significant attention as treatments for type 2 diabetes and weight management. While their effectiveness in controlling blood sugar levels and promoting weight loss is well-documented, the potential side effects and long-term risks associated with these drugs have sparked growing concerns. A. How Ozempic and Wegovy Work Both Ozempic and Wegovy are brand names for semaglutide, a synthetic GLP-1 agonist that mimics a natural hormone in the body. This hormone helps regulate blood sugar, appetite, and digestion. While these medications can be highly effective, they are not without risks. B. Common Side Effects Many users of Ozempic and Wegovy report experiencing side effects, some of which can significantly impact their quality of life: 1. Nausea and Vomiting: These are the most commonly reported side effects, often severe enough to lead to dehydration in some patients. 2. Diarrhea or Constipation: Disruptions to the digestive system are frequent, making daily routines challenging for many. 3. Fatigue: Low energy levels and lethargy are often reported, especially during the initial weeks of treatment. 4. Serious Risks and Long-Term Concerns While common side effects are generally manageable, Ozempic and Wegovy have been linked to more serious health risks: 1. Pancreatitis: Inflammation of the pancreas is a rare but potentially life-threatening condition associated with GLP-1 agonists. 2. Gallbladder Issues: Semaglutide use has been linked to an increased risk of gallbladder disease, including gallstones. 3. Thyroid Tumors: Animal studies suggest a potential link to medullary thyroid carcinoma, although human studies remain inconclusive. 4. Muscle Loss: Rapid weight loss from these drugs can lead to the loss of lean muscle mass, which may harm metabolic health in the long term. Psychological Effects Reports of mental health impacts, such as increased anxiety or changes in mood, are emerging as patients share their experiences. For some, the emotional toll of these side effects outweighs the benefits of weight loss or blood sugar control. Dependency and Rebound Weight Gain Another growing concern is dependency on these medications. Discontinuing Ozempic or Wegovy often leads to rebound weight gain as appetite suppression wanes and the body adjusts, sometimes resulting in regaining more weight than was initially lost. Seeking Safer Alternatives As awareness of these risks grows, patients and healthcare providers are exploring natural, non-invasive alternatives to GLP-1 agonists. Products like Curbix ™, a natural GLP-1 alternative, offer hope by delivering similar metabolic benefits without the severe side effects, needles, or prescription requirements. Informed Choices for Better Health While Ozempic and Wegovy have transformed the lives of many, it’s essential to weigh their benefits against their risks. Always consult your healthcare provider about the potential side effects and consider whether a natural, less invasive solution may be a safer fit for your wellness goals. Your health journey is personal—make it informed.

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View show notes here: https://bit.ly/4exzjNe Become a member to receive exclusive content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ In this “Ask Me Anything” (AMA) episode, Peter dives back into the increasingly popular topic of GLP-1 agonists, such as Ozempic & Mounjaro, which have garnered widespread attention for their ability to promote weight loss. Peter covers the latest findings in this rapidly evolving landscape, including new insights into their long-term efficacy, side effects, & what happens when the drug is discontinued. Peter also explores their impact on body composition & how resistance training interacts with these treatments. Additionally, he compares different GLP-1 receptor agonists & discusses promising new drugs in the pipeline. Finally, Peter addresses questions about the role of compounding pharmacies in the GLP-1 agonist market, compares oral vs. injectable options, & provides key considerations for anyone deciding whether to use a GLP-1 agonist for weight loss. We discuss: 00:09 - The rapidly evolving landscape of GLP-1 agonists 5:14 - The mechanism of GLP-1 agonists, origin as diabetes treatments, & how they evolved into weight-loss drugs 09:08 - Overview of new data & open questions related to the benefits & risks of GLP-1 agonists 16:19 - New insights into the long-term safety of GLP-1 agonists & side effects In the full episode, we also discuss: The long-term efficacy of GLP-1 agonists, financial barriers, & more; The mechanisms behind GLP-1 agonists' ability to promote weight loss; New data on body weight changes after discontinuing the drug; Effects of GLP-1 agonists on lean mass & body composition, & the role of protein & resistance training in preserving muscle; Semaglutide vs. tirzepatide; How compounding pharmacies affect availability of GLP-1 drugs & the available formulations; How oral formulations of GLP-1 drugs compare to injectable formulations; How sublingual (under tongue) formulations of GLP-1 drugs compare to injectable formulations; Guidance for using compounding pharmacies to purchase GLP-1 agonists; Data on retatrutide—a promising new triple receptor agonist in the pipeline; Can GLP-1 agonists be beneficial for sleep apnea & immune function?; Potential neuroprotective benefits of GLP-1 agonists: impact on dementia risk; Exploring why GLP-1 agonists may reduce the risk of cancer, kidney disease, & cardiovascular disease; How GLP-1 agonists might boost fertility in women; Early indications that GLP-1 agonists may help treat substance abuse disorders; Potential health risks of GLP-1 agonists: addressing thyroid cancer concerns & the unknowns due to lack of data; Examining the potential link between GLP-1 agonists & increased depression or suicidal ideation; Major remaining questions: the effects of cyclic use, rebound appetite, impact on adolescents' development, & more; Key considerations when deciding whether to use a GLP-1 agonist for weight loss; -------- About: The Peter Attia Drive is a deep-dive podcast focusing on maximizing longevity, & all that goes into that from physical to cognitive to emotional health. With over 90 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer’s disease, cancer, mental health, & much more. Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan & simultaneously improving their healthspan. Learn more: https://peterattiamd.com Connect with Peter on: Facebook: http://bit.ly/PeterAttiaMDFB Twitter: http://bit.ly/PeterAttiaMDTW Instagram: http://bit.ly/PeterAttiaMDIG Subscribe to The Drive: Apple Podcast: http://bit.ly/TheDriveApplePodcasts Overcast: http://bit.ly/TheDriveOvercast Spotify: http://bit.ly/TheDriveSpotify Google Podcasts: http://bit.ly/TheDriveGoogle Disclaimer: This podcast is for general informational purposes only & does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information & the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, & they should seek the assistance of their healthcare professionals for any such conditions. I take conflicts of interest very seriously. For all of my disclosures & the companies I invest in or advise, please visit my website where I keep an up-to-date & active list of such companies. For a full list of our registered & unregistered trademarks, trade names, & service marks, please review our Terms of Use: https://peterattiamd.com/terms-of-use/

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Which Supplements Support Gut Health On Keto? In this informative video, we discuss essential supplements that can support gut health while following a ketogenic diet. Maintaining a healthy gut is vital for overall well-being, especially when adopting a high-fat, low-carb lifestyle. We will cover various types of supplements that can help promote a balanced gut microbiome, improve digestion, and enhance nutrient absorption. Learn about the role of probiotics and how they contribute to immune function and nutrient absorption. Discover the importance of prebiotics and how they serve as food for beneficial gut bacteria, even within the constraints of a low-carb diet. We will also highlight the significance of magnesium and digestive enzymes, explaining how they can aid in digestion and prevent deficiencies that may arise on a ketogenic diet. This video is packed with practical information to help you navigate your ketogenic journey more smoothly. Whether you are new to keto or looking to optimize your routine, this discussion will provide helpful tips for maintaining gut health. Don't forget to subscribe to our channel for more informative content on the ketogenic diet and other health-related topics. ⬇️ Subscribe to our channel for more valuable insights. 🔗Subscribe: https://www.youtube.com/@KetoKitchenHQ/?sub_confirmation=1 #KetoDiet #GutHealth #Probiotics #Prebiotics #Magnesium #DigestiveEnzymes #HealthyGut #KetoSupplements #Nutrition #KetoLife #LowCarb #FatAdapted #KetoCommunity #Wellness #HealthyEating About Us: Welcome to Keto Kitchen HQ, your go-to channel for everything related to the keto diet. Whether you're a beginner looking to understand Keto Diet Basics or an experienced practitioner refining your approach, we cover a range of topics including Low-Carb Meal Planning, Ketosis Explained, and Keto-Friendly Foods. Our engaging videos will help guide you on your journey with insights into Intermittent Fasting, Keto for Weight Loss, and delicious Ketogenic Recipes.