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Today, we're going to explore an exciting and revolutionary topic: hacking GLP-1 through the gut microbiome. We'll uncover how tiny microorganisms in our gut can influence a powerful hormone that plays a critical role in our health. Stay through to the end to learn why popular GLP-1 drugs like Ozempic may not be a wise choice. Let's jump in! GLP-1, or Glucagon-like peptide-1, is a hormone produced in the intestines. It helps regulate blood sugar levels by enhancing insulin secretion, and it also plays a role in controlling appetite. This makes it incredibly important for managing conditions like diabetes and obesity.

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Is a ketogenic diet an effective, affordable, and sustainable solution for long-term metabolic health? A new publication looking at the real-world implementation of ketogenic therapy challenges the misconception that a ketogenic diet is unsustainable or too expensive. 82% of participants maintained the diet for an entire year, improving their health while saving an average of $1,700 per person by reducing the need for medications by an average of nearly 2 medications per patient. Beyond cost savings, participants lost an average of 43 pounds in one year—results that match or exceed those of GLP-1 medications like Ozempic and Wegovy. At Metabolic Mind, one of our key missions is to increase payor coverage of metabolic therapies, ensuring that cost-effective interventions like ketogenic therapy are accessible to those who need them most. Studies like this one reinforce the idea that ketogenic therapy, with the right support, is a practical, effective, and cost-saving approach to metabolic health. *Studies Mentioned:* _TOWARD, a metabolic health intervention, demonstrates robust 1-year weight loss and cost-savings through deprescription_ - https://doi.org/10.3389/fnut.2025.1548609 Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/. *About us:* Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them. Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications. *Timestamps:* 0:00 - Introduction to Dr. Tro’s new paper on GLP1’s vs ketogenic diet. 1:20 - Is the ketogenic diet sustainable and worth implementing? 2:33 - How much weight did ketogenic dieters lose? How does this compare to GLP1 medications? 2:58 - Why is it important for businesses to consider ketogenic therapy for their workers? 4:38 - Why is this study from Dr. Tro important? What can it help change?

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In this episode of 'The Downsized,' host Laraine Durham shares her personal experience with GLP-1 treatments for obesity, focusing on how to determine when to increase your dosage of medications like Mounjaro, Zepbound, and Ozempic. Laraine, who has lost over 50 pounds using compounded Tirzepatide, explains the importance of starting with a low dose to minimize side effects and how to systematically increase your dose for optimal weight loss. She provides thoughts on dosage intervals and highlights the need for personalized plans based on individual progress and side effects. Laraine emphasizes the value of keeping detailed notes or spreadsheets to track your weight, dosage, and any side effects, encouraging viewers to consult their doctors before making any dosage changes. She also discusses how life events like birthdays and vacations can impact your decision to adjust the dose. Throughout her 67-week journey, she has found specific doses that work best for her, sharing that her most effective dose for weight loss was 7.5 milligrams, though this can vary for others. Laraine concludes by stressing that weight loss should be viewed as a marathon rather than a sprint and advises focusing on a sustainable pace of 1-2 pounds per week. For those in the maintenance phase, she shares tips on managing side effects and maintaining weight. The episode is a comprehensive guide for anyone using GLP-1 medications to assist in their weight loss journey. DOWNSIZED WEBSITE: https://thedownsized.org/ JOIN CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store We use Mochi Health: https://joinmochi.com/. Use Laraine’s code for $40 off: QIYGO8. 00:00 Introduction and Personal Journey 01:00 Understanding GLP-1 Medications 02:21 Dosage Guidelines and Adjustments 03:11 Tracking Progress and Adjusting Doses 04:19 Managing Side Effects and Long-Term Use 04:53 Personal Insights and Tips 06:43 Consistency and Maintenance 08:17 Conclusion and Final Thoughts

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Welcome to Downsized Live with Laraine and Christopher Durham! 🌟 Dive into the transformative world of GLP-1 weight loss with us. As a couple who have experienced the incredible benefits of these medications firsthand, we’re thrilled to share our journey, practical tips, and tricks with you, and build a community together. In this interactive session, we’ll answer all your burning questions about weight management with GLP-1 agonists like Mounjaro, Zepbound, Ozempic, Wegovy, Tirzepatide, and Semaglutide. Don’t miss out – bring your questions and join us on this path to better health! 🌟 🔔 Subscribe and hit the notification bell so you don’t miss the live stream! Link to Laraine's Spreadsheet: https://docs.google.com/spreadsheets/d/1JQWts3StdNWbw2cVCUs7Qt6cWHkiuClTzSuMVOfwrpA/edit?usp=sharing Use Laraine's code for $40 off at Mochihealth.com: get $40 using code QIYGO8