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Yuanyuan Zhang, Alexei Kharitonenkov, and colleagues have developed QL1005, a GLP-1/GDF15 hybrid molecule with balanced pathway activation, which can effectively lower body weight via reductions in caloric intake in multiple animal models. In a non-human primate model of obesity, QL1005’s safety and tolerability are similar to that of incretin-based therapies. Check out the paper at http://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00001-3. Y. Zhang, X. Zhao, X. Dong, Y. Zhang, H. Zou, Y. Jin, W. Guo, P. Zhai, X. Chen, and A. Kharitonenkov (2023). Activity-balanced GLP-1/GDF15 dual agonist reduces body weight and metabolic disorder in mice and non-human primates. Cell Metab. 35. And read more great research at http://www.cell.com/cell-metabolism/home.

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#diabetes #weightloss #diabetesdrug Research Reveals Method to Improve Diabetes and Weight-Loss Drug Performance According to new research from the University of Michigan, a network of proteins found in the central nervous system could be leveraged to enhance the effectiveness and minimize the side effects of popular diabetes and weight-loss medications. The study, published in the Journal of Clinical Investigation, focused on two proteins, melanocortin 3 and melanocortin 4, primarily located on the surface of neurons in the brain. These proteins play a central role in regulating feeding behavior and maintaining the body's energy balance.Melanocortin 3 and 4 influence everything from sensing long-term energy stores to processing gut signals about short-term satiety. GLP-1 agonists, such as semaglutides (e.g., Ozempic) and tirzepatides (e.g., Mounjaro), have gained attention for effectively treating type 2 diabetes, obesity, heart disease, and potentially addiction. These drugs mimic a natural hormone produced by the gut when full, signaling the brain to reduce feeding behavior. In the study, researchers tested the effects of several hormones that reduce food intake in the mouse models and discovered that modifying the melanocortin system made mice more responsive to GLP-1 drugs and other hormones influencing feeding behavior. Mice treated with a combination of a GLP-1 drug and an MC4R agonist or MC3R antagonist experienced up to five times more weight loss and reduced feeding compared to those receiving only GLP-1 drugs. The researchers also measured brain activity in areas associated with nausea from GLP-1 drugs and found no increased activation when these drugs were combined with alterations to the melanocortin system. However, priming melanocortin neurons significantly boosted GLP-1 drug activation in hypothalamic feeding centers. The findings suggested that combining GLP-1 drugs with an MC4R agonist could increase the drugs' effectiveness by up to fivefold without enhancing side effects. This approach could allow patients sensitive to side effects to take lower doses or improve outcomes in those unresponsive to current dosages. Further drug development and clinical testing are needed to advance this strategy. Although this research has only been conducted in mouse models, researchers remain optimistic that the results will translate effectively to humans. "The melanocortin system is highly conserved in humans. Everything we've observed in the mouse over the past decades studying these proteins has also been found in humans, so I suspect that these results would also be translatable to patients,” said Cone, director of the U-M Life Sciences Institute Check full updates on Medical Dialogues Also check out - Medical Dialogues Academy, a renowned academic wing of Medical Dialogues - India's premier health and news online portal, proudly presents this comprehensive course tailored for healthcare professionals eager to delve into the realm of medical journalism. 🔗 Enroll Today: https://academy.medicaldialogues.in/courses/certificate-course-in-medical-journalism/ 📚 Explore More With Us: 📌 Medical Content Writing: https://academy.medicaldialogues.in/courses/medical-content-writing/ 📌 Certificate Course in Pharmaceutical Medico-Marketing: https://academy.medicaldialogues.in/courses/certificate-course-in-pharmaceutical-medico-marketing/ Join us on this enlightening journey and become a part of a community pushing the boundaries of healthcare communication and reporting. Get the latest medical and health news at medicaldialogues.in Follow us on Twitter: https://twitter.com/medicaldialogs Facebook: https://www.facebook.com/medicaldialogues/ Instagram: https://www.instagram.com/medicaldialogues LinkedIn: https://www.linkedin.com/company/medical-dialogues Website: https://medicaldialogues.in/

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Click Here to Subscribe: http://Bit.ly/ThomasVid Website: http://ThomasDeLauer.com Get the Apparel I Wear at http://www.Hylete.com Does a Sauna Benefit You or Improve Fat Loss? - Thomas DeLauer I'm about to totally wow you with the science of how sitting in a sauna for just a short amount of time after a workout or in general can totally shift the way that your body metabolizes energy and shift the way that your body built muscle and burns fat. When we're looking at how a sauna affects the body, we're looking at something known as hyperthermic conditioning. Hyperthermic conditioning is just like the name implies. We're conditioning ourselves to be a little bit more exposed to a higher temperature. With hyperthermic conditioning, we're acclimating our bodies to heat independent of aerobic activity. Normally if you go out for a run or you do some kind of aerobic exercise, your core body temperature is going to go up, simply because you're moving. With hyperthermic conditioning, we're trying to elicit the same response, but without the actual activity. We're just trying to get the core body temperature up and still trying to get the same benefits, and now, the science is showing the benefits are there. Basically what we're doing is we're trying to build a generalized tolerance to physiological stress by adapting to heat. Just like anything, we have an adaptation process that occurs, and when we expose ourselves to a lot of heat, we do have this adaptation that occurs at a cellular level and different metabolic levels. Now the biggest one that we probably know of already is the increase in blood flow and plasma volume. This one kinda goes without saying. When you have more heat, your blood vessels dilate, you get more blood flow, yeah, that's all fine and dandy, but there's a lot of really cool stuff coming out in the way of what are called heat shock proteins. Now the studies that I'm gonna reference in this video, and believe me, there's quite a few of them, are going to really be centered around heat shock proteins and what these heat shock proteins do for not only your recovery, but your overall metabolism. A heat shock protein is a highly conserved protein that sits inside of a cell. Every single organism has them and every single cell has heat shock proteins. They're proteins that sit in a reserve mode, waiting to get acted upon by high stress, for instance, high heat. That's why they're called heat shock proteins. When our cells are exposed to heat shock, these proteins are released, and they protect what are called the folding and unfolding of these different proteins inside of a cell. Inside of a cell, when you build a cell, you have proteins that fold on top of each other. Now sometimes they unfold, sometimes they fold, so these heat shock proteins stabilize them. They hold them in place so that they have a little bit more time to recover when exposed to extreme conditions like high heat. References 1) Li Z and Srivastava P. (n.d.). Heat-shock proteins. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/18432918 2) Heat shock proteins - an overview | ScienceDirect Topics. (n.d.). Retrieved from https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/heat-shock-proteins 3) Heat Stress and Cardiovascular, Hormonal, and Heat Shock Proteins in Humans. (2012, March). Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418130/ 4) Selsby JT , et al. (n.d.). Intermittent hyperthermia enhances skeletal muscle regrowth and attenuates oxidative damage following reloading. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/17110516 5) Wei Q , et al. (n.d.). Heme oxygenase-1 induction contributes to renoprotection by G-CSF during rhabdomyolysis-associated acute kidney injury. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/21511696 6) Costa RJ , et al. (n.d.). Heat acclimation responses of an ultra-endurance running group preparing for hot desert-based competition. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/24444197 7) Scoon GS , et al. (n.d.). Effect of post-exercise sauna bathing on the endurance performance of competitive male runners. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/16877041 8) Kukkonen-Harjula K , et al. (n.d.). Haemodynamic and hormonal responses to heat exposure in a Finnish sauna bath. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/2759081 9) Laatikainen T , et al. (n.d.). Response of plasma endorphins, prolactin and catecholamines in women to intense heat in a sauna. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/2830109 10) Running enhances neurogenesis, learning, and long-term potentiation in mice. (9, November). Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC23964/

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While Fat Burning Keto Gummies are specifically designed to support a ketogenic diet, you can still benefit from their fat-burning properties even if you’re not following a strict keto plan. However, for optimal results, it’s recommended to pair Fat Burning Keto Gummies with a low-carb, high-fat diet and regular exercise.

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Some people may experience mild side effects when first starting to take Fat Burning Keto Gummies, such as digestive issues or headaches. These symptoms are usually temporary and should subside as your body adjusts to the supplement. If you experience persistent or severe side effects, discontinue use and consult with a healthcare professional.

5. Where can I purchase Fat Burning Keto Gummies?

Fat Burning Keto Gummies are available for purchase online through various retailers and health supplement stores. Be sure to buy from a reputable source to ensure that you’re getting a high-quality product that meets safety standards. Check the ingredients list and reviews before making a purchase to ensure that Fat Burning Keto Gummies are the right choice for you.

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