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❌ Non è cosa mangi… ✅ È quanto ne mangi. ➡️ Una fetta di torta non rovinerà la tua dieta. Ma tornare per la seconda, la terza… e abbinarla a 4 birre? Ecco dove il dimagrimento si blocca. La vera chiave per perdere grasso non è privarsi dei cibi che ami. È smettere di esagerare. 📊 Moderazione maggiore di Restrizione. Sempre. 🍕 Vuoi un piano semplice per perdere grasso senza rinunciare ai tuoi cibi preferiti? Scrivi nei commenti “2025” e ti spiego come abbiamo trasformato oltre 8500 persone impegnate che hanno perso dai 5 ai 15kg nei primi 3 mesi! 📩 Ideale per chi vuole dimagrire senza complicazioni o rinunce estreme. 👉 Condividi questo reel con chi pensa di aver “mandato all’aria la dieta” per un solo sgarro. Seguimi per altri consigli su nutrizione facile e fitness sostenibile 💪 #dimagrirecongusto #perditadipeso #sgarrointelligente #fitnessitalia #nutrizioneflessibile #alimentazionesana #dimagrirefacile #fitnessefficace #moderazione #pianodimagrimento #fitnesssenzaansia #dimagrire

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Dewberry discusses our work on the Carlisle Road Diet—a complete streets and traffic calming initiative project—in Cumberland County, Pennsylvania. Transcript: The Carlisle Road Diet in Cumberland County, Pennsylvania, was a complete streets and traffic calming initiative, completed in 2011. As a result of our comprehensive traffic study, we made several recommendations for traffic pattern changes that were in line with PennDOT's Smart Transportation Initiative. Two streets were converted from four vehicular lanes to three, with a dedicated bike lane in each direction. The bike lanes also provide easier parallel parking and a safer space to enter and exit parked cars. Additional improvements were accomplished through curb extensions; ADA curb ramps; pedestrian signals enhancements; and major traffic signal upgrades, including the first full implementation of the InSync® adaptive signal system in Pennsylvania. All of these improvements enhance Carlisle's small town feeling; reduce accidents; promote walking and bicycling; maximize downtown business success; improve parking access; and reduce truck traffic in the downtown area.

Transform Your Body The Secret To Building Muscle And Losing Weight Health

In this powerful 21-minute motivational speech, discover the 3 scientifically backed secrets to losing fat without sacrificing muscle. This isn’t just about looking better—it’s about mastering your biology. Inspired by neuroscience and behavior change psychology, this talk reveals how your brain can either help or hinder your body transformation goals. You'll learn how to protect muscle mass, optimize fat burning, and most importantly, rewire your mindset to stay consistent without burning out. This isn’t about crash diets or shortcuts—it’s about using your brain and body in sync to achieve lasting change. Whether you're just starting your journey or looking to break through a plateau, these insights will give you the mental edge you need to reshape your body and maintain strength. Why You Should Watch If you’ve been stuck trying to burn fat while keeping your hard-earned muscle, you’re not alone. Most people approach fat loss the wrong way—leading to muscle breakdown, low energy, and frustration. But the problem isn’t just in your diet or workouts. The real transformation begins in your brain. This video delivers the mindset, the science, and the daily structure to lose fat smartly, preserve lean muscle, and stay mentally sharp throughout the process. Watch it to shift your approach, sharpen your strategy, and condition your brain to support long-term success—without extremes or setbacks. Timestamps 00:00 – 🔥 Introduction: The Fat Loss & Muscle Paradox 02:12 – 🧠 Why the Brain Matters More Than Macros 05:06 – 💪 Secret 1: Protect Muscle With Neural Consistency 08:41 – 🔁 How to Trigger Fat Burn Without Muscle Loss 11:19 – 🎯 Secret 2: Train Smart, Not Just Hard 14:22 – ⚖️ Balance Energy & Recovery 17:03 – 🚀 Secret 3: Use Dopamine to Stay Disciplined 19:37 – 🧱 Structure Your Routine for Sustainable Progress Hashtags #fatlosswithoutmuscleloss, #andrewhubermaninspired, #musclepreservation, #neurosciencefitness, #burnfatbuildmuscle, #fitnessmotivation, #mentaldiscipline, #healthoptimization, #bodytransformation, #brainandbody, #dopaminemotivation, #fitnessconsistency, #trainyourmind, #smartfatloss, #fatburningtips, #sciencebasedfitness, #selfimprovement, #mindsetmatters, #weightlossmotivation, #musclebuildingmindset, #highperformancelifestyle, #habitsforfatloss, #fatlossjourney, #neurofitness, #motivationalfitnessspeech Keywords how to lose fat without losing muscle, neuroscience and fat loss, build muscle while losing fat, mindset for fat loss, Andrew Huberman speech, fat loss motivation, preserve muscle mass, dopamine and training, discipline for body transformation, how to train smart, structured fat loss, motivational fat loss video, consistent training mindset, brain rewiring for weight loss, fitness transformation strategy, avoid muscle loss during fat loss, fat loss without burnout, motivation for lean body, mind body connection fitness, behavioral change fitness, motivation 2025 fat loss, fitness goal consistency, high performance training, strength-focused fat loss, balance recovery and training

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To cite: Senni N, Savall M, Cabrerizo Granados D, et al. Gut 2019;68:322-334. Read the full article here: http://dx.doi.org/10.1136/gutjnl-2017-315448. Objectives: CTNNB1-mutated hepatocellular carcinomas (HCCs) constitute a major part of human HCC and are largely inaccessible to target therapy. Yet, little is known about the metabolic reprogramming induced by β-catenin oncogenic activation in the liver. We aimed to decipher such reprogramming and assess whether it may represent a new avenue for targeted therapy of CTNNB1-mutated HCC. Conclusions: FAO induced by β-catenin oncogenic activation in the liver is the driving force of the β-catenin-induced HCC. Inhibiting FAO by genetic and pharmacological approaches blocks HCC development, showing that inhibition of FAO is a suitable therapeutic approach for CTNNB1-mutated HCC.

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Nuu3 Gummies are available at Walmart and are a convenient and accessible way for individuals to effectively manage their weight. They are gummies that will help you supplement your dietary intake in a tasty manner as you aim to lose weight. Nuu3 Gummies are currently sold at Walmart where they can be found in the best flavors that make it easier for the user to maintain a healthy lifestyle.

Nuu3 Gummies: A Convenient Option for Weight Management

The convenience of Nuu3 Gummies is that they have no hassle attached. They won’t make you change your diet or carry around things that are so heavy unlike other conventional sliming solutions. If you’re home, at work, or on the road, you can easily take a delicious Nuu3 Gummy to support your weight management goals.

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The Benefits of Nuu3 Gummies

There are several reasons why including Nuu3 Gummies in one’s plan of losing weight is a good idea. In particular, these gummy bears consist of superior ingredients ideal for promoting weight loss. Be it metabolic enhancers or hunger suppressors, Nuu3 Gummie comes with specific formulation which aids people interested in shedding off some pounds.

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The Weight Loss Supplement That Actually Works In Usa

Weight management in patients with obesity and type 2 diabetes is a critical aspect of their overall health. Two medications that have shown promising results in aiding weight loss are Tirzepatide and Semaglutide. Both medications belong to the class of glucagon-like peptide-1 (GLP-1) receptor agonists and have been studied extensively for their efficacy in weight reduction. In this article, we will compare the dosage and effectiveness of Tirzepatide and Semaglutide for optimal weight loss outcomes.

How do Tirzepatide and Semaglutide Differ in Dosage?

Tirzepatide is a novel dual GIP and GLP-1 receptor agonist that has shown significant weight loss effects in clinical trials. The recommended starting dose of Tirzepatide is 5 mg once a week, with the option to increase to 10 mg once a week after four weeks if tolerated. On the other hand, Semaglutide is a well-established GLP-1 receptor agonist that has also demonstrated substantial weight loss benefits.

The recommended starting dose of Semaglutide for weight loss is 0.25 mg once a week for four weeks, followed by an increase to 0.5 mg once a week. For some patients who need additional weight loss support, a further increase to 1.0 mg once a week may be considered. It is important to note that both medications should be used in conjunction with a reduced-calorie diet and increased physical activity for optimal weight loss results.

Effectiveness of Tirzepatide in Weight Loss

Multiple studies have highlighted the effectiveness of Tirzepatide in promoting weight loss in patients with obesity and type 2 diabetes. In a phase 2 trial, patients treated with Tirzepatide achieved an average weight loss of 11.3% after 72 weeks of treatment. This substantial weight reduction was maintained throughout the study duration, demonstrating the long-term efficacy of Tirzepatide in managing body weight.

Furthermore, another study compared the weight loss effects of Tirzepatide with Semaglutide and found that Tirzepatide produced superior weight loss outcomes. Patients treated with Tirzepatide experienced a greater reduction in body weight and waist circumference compared to those receiving Semaglutide, suggesting that Tirzepatide may be more potent in promoting weight loss.

Benefits of Semaglutide in Weight Management

Semaglutide has been extensively studied for its weight loss benefits in patients with obesity and type 2 diabetes. In the STEP trials, Semaglutide was shown to induce significant weight loss in individuals with obesity, with some participants achieving weight reductions of up to 15% or more. This remarkable weight loss effect has positioned Semaglutide as a leading medication for obesity management.

Moreover, Semaglutide has demonstrated additional health benefits beyond weight loss, including improvements in glycemic control, blood pressure, and lipid profiles. These favorable metabolic effects make Semaglutide a valuable option for patients with obesity and comorbidities who require comprehensive metabolic management.

Comparison of Side Effects and Tolerability

While both Tirzepatide and Semaglutide are generally well-tolerated, they may cause some side effects that vary in frequency and intensity. Common side effects of Tirzepatide include gastrointestinal symptoms such as nausea, diarrhea, and vomiting. These side effects are usually mild to moderate and tend to improve over time as the body adjusts to the medication.

On the other hand, Semaglutide may also cause gastrointestinal adverse effects, including nausea, vomiting, and constipation. However, these side effects are typically transient and diminish with continued use. It is essential for patients to communicate any adverse reactions to their healthcare provider to ensure appropriate management and support. Via Keto Now At Chemist Warehouse Ketosis Made Accessible

Conclusion

In conclusion, Tirzepatide and Semaglutide are both effective medications for weight loss in patients with obesity and type 2 diabetes. The choice between Tirzepatide and Semaglutide should be based on individual patient factors, including treatment goals, tolerability, and preferences. Both medications offer substantial weight loss benefits and can significantly improve metabolic parameters in individuals with obesity.