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Over a quarter of the Indian adult population is either obese, at risk of diabetes or are diabetic. This has become a marketing & business opportunity for a lot of fitness & healthtech companies with plain vanilla no science interventions focussed on either high protein, calorie counting, CGM driven or at worst GLP-1 drugs. But these companies fail to understand how human biochemistry works. These interventions, if they help in weight loss, is a stop gap arrangement. Weight gain is not the cause but the effect & symptom. Obesity is triggered by low grade chronic inflammation & our body tries its best to maintain a metabolic homeostasis. However, regular insults we do to our body by consuming toxins or ingesting those foods that are transformed by your microbiome into toxins or pro-inflammatory metabolites makes it hard for us to lose weight. Some of these metabolites include LPS, TMAO, P-cresol & more. While microbes living in our mouth & gut also produce certain beneficial metabolites & incretin hormones ( providing we are feeding them with the right food substrates) that maintain our metabolic health & make it hard for us to gain weight. One of the most important metabolites ( incretin hormone) is GLP-1. Yes, our body automatically produces GLP-1 by synthesising fibre & polyphenols in the food we eat. GLP-1 has multiple benefits via regulating various metabolic pathways-regulates blood sugar response, communicates with brain via gut-brain axis , telling that you are full & even tells stomach & intestine to slow the movement of digestive tract. However, these GLP-1 drugs which lot of companies claim mimics natural GLP-1 brings multiple side effects & just ingesting these drugs does not mean it will help you lose weight. -Effectiveness of GLP-1 drugs depends upon the functions of your microbiome. Certain microbes can synthesise these drugs into beneficial stuff that have positive correlation with glycemic reduction while some others if active & expressing virulence genes can interfere with synthesis of GLP-1 drugs . -Certain microbes if active & expressing virulence genes can degrade GLP-1, making you gain weight or develop type 2 diabetes. In such scenario, these drugs cannot help. -It has been found that obese have underexpressed NOS attributed to overexpression of tumour necrosis factor-α caused by microbial derived endotoxin LPS. Besides, there are multiple other factors that can suppress NOS/cause endothelial cell dysfunction such as overexpression of ADMA, oxidative stress( caused by P-cresol &/or Indoxyl Sulphate Production), TMAO & more. In order to understand the root cause of obesity, there is a need to understand multiple molecular pathways that trigger its onset/progression. We at Genefitletics measures these pathways to construct nutritional therapeutics interventions aligned with your biochemistry that reinstates yout metabolic homeostasis Citations https://pmc.ncbi.nlm.nih.gov/articles/PMC4112002/ https://pmc.ncbi.nlm.nih.gov/articles/PMC7021470/ https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.14725 https://pmc.ncbi.nlm.nih.gov/articles/PMC10391832/ https://diabetesjournals.org/care/article/33/2/453/27096/GLP-1-Based-Therapy-for-Diabetes-What-You-Do-Not https://pmc.ncbi.nlm.nih.gov/articles/PMC5082693/ #obesity #obesityfreeindia #obesityfreenation #obesityawareness #viralvideo #virlshort #viralreels #viral_video #viralshorts #viralnews #healthnews #healthtips #health #healthylifestyle #supplements #obesitymedicine #obesityprevention #obesityawareness #type2diabetes #diabetesawareness #diabetesmanagement #diabetescare #diabetescure

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